3D simulations of gyrosynchrotron emission from mildly anisotropic nonuniform electron distributions in symmetric magnetic loops

Microwave emission of solar flares is formed primarily by incoherent gyrosynchrotron radiation generated by accelerated electrons in coronal magnetic loops. The resulting emission depends on many factors, including pitch-angle distribution of the emitting electrons and the source geometry. In this work, we perform systematic simulations of solar microwave emission using recently developed tools (GS Simulator and fast gyrosynchrotron codes) capable of simulating maps of radio brightness and polarization as well as spatially resolved emission spectra. A 3D model of a symmetric dipole magnetic loop is used. We compare the emission from isotropic and anisotropic (of loss-cone type) electron distributions. We also investigate effects caused by inhomogeneous distribution of the emitting particles along the loop. It is found that effect of the adopted moderate electron anisotropy is the most pronounced near the footpoints and it also depends strongly on the loop orientation. Concentration of the emitting particles at the loop top results in a corresponding spatial shift of the radio brightness peak, thus reducing effects of the anisotropy. The high-frequency (around 50 GHz) emission spectral index is specified mainly by the energy spectrum of the emitting electrons; however, at intermediate frequencies (around 10-20 GHz), the spectrum shape is strongly dependent on the electron anisotropy, spatial distribution, and magnetic field nonuniformity. The implications of the obtained results for the diagnostics of the energetic electrons in solar flares are discussed.Comment: ApJ in press. 20 pp, 13 figs, on-line album and simulation source code availabl

A note on "Constraints on deep-seated zonal winds inside Jupiter and Saturn"

Liu et al. 2008 discuss an important consideration for models of zonal winds deep within giant planets. However, the constraints they propose for the depth of the winds are based on their prescriptions for the internal structures of the magnetic field and zonal winds. The same kinematic analysis applied to other plausible configurations would produce no constraint on the depth to which the winds extend.Comment: accepted for publication in Icaru

Report of the Dark Energy Task Force

Dark energy appears to be the dominant component of the physical Universe, yet there is no persuasive theoretical explanation for its existence or magnitude. The acceleration of the Universe is, along with dark matter, the observed phenomenon that most directly demonstrates that our theories of fundamental particles and gravity are either incorrect or incomplete. Most experts believe that nothing short of a revolution in our understanding of fundamental physics will be required to achieve a full understanding of the cosmic acceleration. For these reasons, the nature of dark energy ranks among the very most compelling of all outstanding problems in physical science. These circumstances demand an ambitious observational program to determine the dark energy properties as well as possible

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease. Here, using a combination of chemical kinetics, NMR spectroscopy and other biophysical methods, we identify and structurally characterize the oligomers required for amyloid assembly of the protein ΔN6, a truncation variant of human β2-microglobulin (β2m) found in amyloid deposits in the joints of patients with dialysis-related amyloidosis. The results reveal an assembly pathway which is initiated by the formation of head-to-head non-toxic dimers and hexamers en route to amyloid fibrils. Comparison with inhibitory dimers shows that precise subunit organization determines amyloid assembly, while dynamics in the C-terminal strand hint to the initiation of cross-β structure formation. The results provide a detailed structural view of early amyloid assembly involving structured species that are not cytotoxic

Simple Sequence Repeats in the National Longitudinal Study of Adolescent Health: An Ethnically Diverse Resource for Genetic Analysis of Health and Behavior

Simple sequence repeats (SSRs) are one of the earliest available forms of genetic variation available for analysis and have been utilized in studies of neurological, behavioral, and health phenotypes. Although findings from these studies have been suggestive, their interpretation has been complicated by a variety of factors including, among others, limited power due to small sample sizes. The current report details the availability, diversity, and allele and genotype frequencies of six commonly examined SSRs in the ethnically diverse, population-based National Longitudinal Study of Adolescent Health (Add Health). A total of 106,743 genotypes were generated across 15,140 participants that included four microsatellites and two di-nucleotide repeats in three dopamine genes (DAT1, DRD4, DRD5), the serotonin transporter (5HTT), and monoamine oxidase A (MAOA). Allele and genotype frequencies showed a complex pattern and differed significantly between populations. For both di-nucleotide repeats we observed a greater allelic diversity than previously reported. The availability of these six SSRs in a large, ethnically diverse sample with extensive environmental measures assessed longitudinally offers a unique resource for researchers interested in health and behavior

Mastering the Hard Stuff: The History of College Concrete-Canoe Races and the Growth of Engineering Competition Culture

This article details the history of college engineering competitions, originating with student concrete-canoe racing in the 1970s, through today’s multi-million-dollar international multiplicity of challenges. Despite initial differences between engineering educators and industry supporters over the ultimate purpose of undergraduate competitions, these events thrived because they evolved to suit many needs of students, professors, schools, corporations, professional associations, and the engineering profession itself. The twenty-first-century proliferation of university-level competitions in turn encouraged a trickling-down of technical contests to elementary-age children and high schools, fostering the institutionalization of what might be called a competition culture in engineering

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy